Genome-wide association reveals host-specific genomic traits in Escherichia coli.

ABSTRACT:

Background

Escherichia coli is an opportunistic pathogen which colonizes various host species. However, to what extent genetic lineages of E. coli are adapted or restricted to specific hosts and the genomic determinants of such adaptation or restriction is poorly understood.

Results

We randomly sampled E. coli isolates from four countries (Germany, UK, Spain, and Vietnam), obtained from five host species (human, pig, cattle, chicken, and wild boar) over 16 years, from both healthy and diseased hosts, to construct a collection of 1198 whole-genome sequenced E. coli isolates. We identified associations between specific E. coli lineages and the host from which they were isolated. A genome-wide association study (GWAS) identified several E. coli genes that were associated with h

SUBMITTER: Tiwari SK 

PROVIDER: S-EPMC10088187 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature