European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention-part 1: amitriptyline.

ABSTRACT:

Objective

The aim of this paper is to critically re-appraise the published trials assessing amitriptyline for migraine prophylaxis.

Methods

We report our methods and results following the Preferred Reporting Items for Systematic Reviews (PRISMA), by searching MEDLINE, EMBASE, Cochrane CENTRAL, and ClinicalTrials.gov for randomized trials of pharmacologic treatments for migraine prophylaxis. We included randomized trials that compared amitriptyline with placebo for migraine prophylaxis in adults. Our outcomes of interest were informed by the Outcome Set for preventive intervention trials in chronic and episodic migraine (COSMIG) and include the proportion of patients who experience a 50% or more reduction in migraine days per month, migraine days per month, and adverse events

SUBMITTER: Lampl C 

PROVIDER: S-EPMC10088191 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature