The P2X3 receptor antagonist filapixant in patients with refractory chronic cough: a randomized controlled trial.

ABSTRACT:

Background

P2X3 receptor antagonists seem to have a promising potential for treating patients with refractory chronic cough. In this double-blind, randomized, placebo-controlled study, we investigated the efficacy, safety, and tolerability of the novel selective P2X3 receptor antagonist filapixant (BAY1902607) in patients with refractory chronic cough.

Methods

Following a crossover design, 23 patients with refractory chronic cough (age: 60.4 ± 9.1 years) received ascending doses of filapixant in one period (20, 80, 150, and 250 mg, twice daily, 4-days-on/3-days-off) and placebo in the other. The primary efficacy endpoint was the 24-h cough frequency on Day 4 of each dosing step. Further, subjective cough severity and health-related quality of life were assessed.

Results</

SUBMITTER: Friedrich C 

PROVIDER: S-EPMC10088222 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature