Toxic effect window of ovarian development in female offspring mice induced by prenatal prednisone exposure with different doses and time.

ABSTRACT:

Background

Prednisone is one of the most used synthetic glucocorticoids during pregnancy. Epidemiological investigations suggested that prenatal prednisone therapy could affect fetal development, but systematic studies on its effects on ovarian development and the "toxic effect window" remained scarce.

Methods

In this study, by simulating clinical application characteristics, Kunming mice were given prednisone by oral gavage with different doses (0.25 or 1.0 mg/kg·d) or at different time gestational days (GD) (GD0-9, GD10-18, or GD0-18). Blood and ovaries of fetal mice were collected on GD18, and the serum estradiol level and the related function indexes of ovarian granulosa cells and oocytes were detected.

Results

Compared with the control group, prenatal prednisone

SUBMITTER: Huang J 

PROVIDER: S-EPMC10088227 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature