Co-crystal of nadifloxacin with oxalic acid

ABSTRACT: The nadifloxacin oxalic acid co-crystal is stabilized by inter­molecular hydrogen bonds. FT–IR, DSC and XRD studies were carried out to confirm the structure and a Hirshfeld surface analysis was performed to investigate the inter­molecular inter­actions. The 2:1 co-crystal of nadifloxacin [systematic name: 9-fluoro-8-(4-hy­droxy­piperidin-1-yl)-5-methyl-1-oxo-6,7-di­hydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carb­oxy­lic acid] with oxalic acid, C19H21FN2O4·0.5C2H2O4, was prepared by slow evaporation from a chloro­form:acetone solvent system. Nadifloxacin belongs to the group of anti­bacterial drugs. The co-crystal is stabilized through an intra­molecular O—H⋯O bond and inter­molecular hydrogen bonds. It was studied by FT–IR spectroscopy, differential scanning calorimetry and X-ray diffraction

SUBMITTER: Karthammaiah G 

PROVIDER: S-EPMC10088309 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature