Evaluation of the antiviral potential of gemini surfactants against influenza virus H1N1.

ABSTRACT: Influenza A virus (IAV) affects human health worldwide as a high-risk disease. It can neither be easily controlled by current vaccines and nor be treated by conventional drugs. Gemini surfactants (GS) have shown several properties including antiviral activity. In this study, the antiviral capacity of some GS compounds with different levels of hydrophobicity was examined. The 50% cytotoxic (CC₅₀) and non-cytotoxic (NCTC) concentrations of the compounds were determined by MTT method. The NCTCs, the same as effective concentrations (EC₅₀s), were tested for the antiviral capacity against IAV in different combination treatments for 1 h incubation on MDCK cells. The HA and MTT assays were used to evaluate the virus titer and cell viabilities, respectively. The hemolytic act

SUBMITTER: Khodsiani M 

PROVIDER: S-EPMC10088587 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature