The effect of liposomal bupivacaine for surgical wound infiltration: A meta-analysis of randomised controlled trials.

ABSTRACT: Liposomal bupivacaine (LB) has consistently been considered a potential analgesic for surgical wound infiltration. However, the evidence of its analgesic effectiveness remains unclear. In this meta-analysis, we attempted to identify the potential clinical role of LB wound infiltration in different surgical procedures. Randomised controlled trials (RCTs) comparing LB with non-liposomal local anaesthetics and placebos were retrieved from six electronic databases. The primary outcome was cumulative morphine equivalent consumption within 24, 48, and 72 hours after surgery. Approximately 2659 patients from 22 studies were included in the meta-analysis. Compared to the control, LB-wound infiltration did not reduce the postoperative morphine consumption at 24 hours (weighted mean difference [WMD]

SUBMITTER: Jiang H 

PROVIDER: S-EPMC10088822 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature