The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks.

ABSTRACT: Functional connectivity within resting-state networks (RSN-FC) is vital for cognitive functioning. RSN-FC is heritable and partially translates to the anatomic architecture of white matter, but the genetic component of structural connections of RSNs (RSN-SC) and their potential genetic overlap with RSN-FC remain unknown. Here, we perform genome-wide association studies (N _discovery = 24,336; N _replication = 3412) and annotation on RSN-SC and RSN-FC. We identify genes for visual network-SC that are involved in axon guidance and synaptic functioning. Genetic variation in RSN-FC impacts biological processes relevant to brain disorders that previously were only phenotypically associated with RSN-FC alterations. Correlations of the genetic components of RSNs

SUBMITTER: Tissink E 

PROVIDER: S-EPMC10089056 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature