Control of contextual memory through interneuronal α5-GABA_A receptors.

ABSTRACT: γ-Aminobutyric acid type A receptors that incorporate α5 subunits (α5-GABA_ARs) are highly enriched in the hippocampus and are strongly implicated in control of learning and memory. Receptors located on pyramidal neuron dendrites have long been considered responsible, but here we report that mice in which α5-GABA_ARs have been eliminated from pyramidal neurons (α5-pyr-KO) continue to form strong spatial engrams and that they remain as sensitive as their pseudo-wild-type (p-WT) littermates to etomidate-induced suppression of place cells and spatial engrams. By contrast, mice with selective knockout in interneurons (α5-i-KO) no longer exhibit etomidate-induced suppression of place cells. In addition, the strength of spatial engrams is lower in α5-i-KO mice than p-WT litte

SUBMITTER: Zhu M 

PROVIDER: S-EPMC10089065 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature