Dysconnection and cognition in schizophrenia: A spectral dynamic causal modeling study.

ABSTRACT: Schizophrenia (SZ) is a severe mental disorder characterized by failure of functional integration (aka dysconnection) across the brain. Recent functional connectivity (FC) studies have adopted functional parcellations to define subnetworks of large-scale networks, and to characterize the (dys)connection between them, in normal and clinical populations. While FC examines statistical dependencies between observations, model-based effective connectivity (EC) can disclose the causal influences that underwrite the observed dependencies. In this study, we investigated resting state EC within seven large-scale networks, in 66 SZ and 74 healthy subjects from a public dataset. The results showed that a remarkable 33% of the effective connections (among subnetworks) of the cognitive control network

SUBMITTER: Zarghami TS 

PROVIDER: S-EPMC10089110 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature