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Synthesis of Ti₃C₂T _x /MnO₂ composites for synergistic catalytic/photothermal-based bacterial inhibition.

ABSTRACT: Human inflammation caused by bacterial infection threatens global public health. The abuse of antibiotics often leads to the development of drug resistance in bacteria. To address this issue, nanozymes with peroxidase-like (POD-like) activity have often been reported for bacteriostasis with the assistance of catalytic substrate hydrogen peroxide (H₂O₂). However, it is difficult to achieve efficient bactericidal outcomes only through exertion of the POD-like activity of nanozymes. Here, MnO₂ loaded Ti₃C₂T _x (Ti₃C₂T _x /MnO₂) was prepared by a two-step reaction method, in which MnO₂ showed high oxidase-like (OXD-like) activity to elevate the levels of reactive oxygen species (ROS) without H₂O₂ and Ti₃C₂T _x exhibited high photothermal conversion efficiency to induce hyperthermia. Thus, the obtained Ti₃C₂T _x /MnO₂ realized synergistic catalytic/photothermal-based bacterial inhibition, including for Gram-negative bacteria (Escherichia coli), Gram-positive bacteria (Staphylococcus aureus), and methicillin-resistant Staphylococcus aureus. Importantly, Ti₃C₂T _x /MnO₂ with near-infrared light irradiation successfully promoted Staphylococcus aureus-infected wound healing in mouse models, representing an alternative treatment to fight against bacterial infection.

SUBMITTER: Hu T

PROVIDER: S-EPMC10089122 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Synthesis of Ti3C2T x /MnO2 composites for synergistic catalytic/photothermal-based bacterial inhibition.

Hu Ting T Xu Zhilong Z Zhang Peiying P Fan Lei L Xi Juqun J Han Jie J Guo Rong R

Nanoscale advances 20230228 8

Human inflammation caused by bacterial infection threatens global public health. The abuse of antibiotics often leads to the development of drug resistance in bacteria. To address this issue, nanozymes with peroxidase-like (POD-like) activity have often been reported for bacteriostasis with the assistance of catalytic substrate hydrogen peroxide (H2O2). However, it is difficult to achieve efficient bactericidal outcomes only through exertion of the POD-like activity of nano ...[more]

PMID: 37056616

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Project description:Posterior capsule opacification (PCO) is one of the most frequent late-onset complications after cataract surgery. Several kinds of drug-eluting intraocular lenses (IOL) were designed for sustainable drug release to suppress ocular inflammation, the proliferation of lens epithelial cells (LECs) and the development of PCO after cataract surgery. Despite previous advances in this field, the drug-loaded IOLs were limited in ocular toxicity, insufficient drug-loading capacity, and short release time. To prevent PCO and to address these drawbacks, a novel drug-loaded IOL (Rapa@Ti3C2-IOL), prepared from two-dimensional ultrathin Ti3C2 MXene nanosheets and rapamycin (Rapa), was fabricated with a two-step spin coating method in this study. Rapa@Ti3C2 was prepared via electrostatic self-assembly of Ti3C2 and Rapa, with a loading capacity of Rapa at 92%. Ti3C2 was used as a drug delivery reservoir of Rapa. Rapa@Ti3C2-IOL was designed to have the synergistic photothermal and near infrared (NIR)-controllable drug release property. As a result, Rapa@Ti3C2-IOL exhibited the advantages of simple preparation, high light transmittance, excellent photothermal conversion capacity, and NIR-controllable drug release behavior. The Rapa@Ti3C2 coating effectively eliminated the LECs around Rapa@Ti3C2-IOL under a mild 808-nm NIR laser irradiation (1.0 W/cm-2). Moreover, NIR-controllable Rapa release inhibited the migration of LECs and suppressed the inflammatory response after photothermal therapy in vitro. Then, Rapa@Ti3C2-IOL was implanted into chinchilla rabbit eyes, and the effectiveness and biocompatibility to prevent PCO were evaluated for 4 weeks. The Rapa@Ti3C2-IOL implant exhibited excellent PCO prevention ability with the assistance of NIR irradiation and no obvious pathological damage was observed in surrounding healthy tissues. In summary, the present study offers a promising strategy for preventing PCO via ultrathin Ti3C2 MXene nanosheet-based IOLs with synergistic photothermal and NIR-controllable Rapa release properties.

Dataset Information

Synthesis of Ti₃C₂T _x /MnO₂ composites for synergistic catalytic/photothermal-based bacterial inhibition.

Publications

Synthesis of Ti<sub>3</sub>C<sub>2</sub>T <sub><i>x</i></sub> /MnO<sub>2</sub> composites for synergistic catalytic/photothermal-based bacterial inhibition.

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