Quantifying heterogeneity to drug response in cancer-stroma kinetics.

ABSTRACT: A crucial challenge in medicine is choosing which drug (or combination) will be the most advantageous for a particular patient. Usually, drug response rates differ substantially, and the reasons for this response unpredictability remain ambiguous. Consequently, it is central to classify features that contribute to the observed drug response variability. Pancreatic cancer is one of the deadliest cancers with limited therapeutic achievements due to the massive presence of stroma that generates an environment that enables tumor growth, metastasis, and drug resistance. To understand the cancer-stroma cross talk within the tumor microenvironment and to develop personalized adjuvant therapies, there is a necessity for effective approaches that offer measurable data to monitor the effect of drugs

SUBMITTER: Alemanno F 

PROVIDER: S-EPMC10089157 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature