Propofol disrupts alpha dynamics in functionally distinct thalamocortical networks during loss of consciousness.

ABSTRACT: During propofol-induced general anesthesia, alpha rhythms measured using electroencephalography undergo a striking shift from posterior to anterior, termed anteriorization, where the ubiquitous waking alpha is lost and a frontal alpha emerges. The functional significance of alpha anteriorization and the precise brain regions contributing to the phenomenon are a mystery. While posterior alpha is thought to be generated by thalamocortical circuits connecting nuclei of the sensory thalamus with their cortical partners, the thalamic origins of the propofol-induced alpha remain poorly understood. Here, we used human intracranial recordings to identify regions in sensory cortices where propofol attenuates a coherent alpha network, distinct from those in the frontal cortex where it amplifies cohe

SUBMITTER: Weiner VS 

PROVIDER: S-EPMC10089159 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature