Larger cerebral cortex is genetically correlated with greater frontal area and dorsal thickness.

ABSTRACT: Human cortical expansion has occurred non-uniformly across the brain. We assessed the genetic architecture of cortical global expansion and regionalization by comparing two sets of genome-wide association studies of 24 cortical regions with and without adjustment for global measures (i.e., total surface area, mean cortical thickness) using a genetically informed parcellation in 32,488 adults. We found 393 and 756 significant loci with and without adjusting for globals, respectively, where 8% and 45% loci were associated with more than one region. Results from analyses without adjustment for globals recovered loci associated with global measures. Genetic factors that contribute to total surface area of the cortex particularly expand anterior/frontal regions, whereas those contributing to th

SUBMITTER: Makowski C 

PROVIDER: S-EPMC10089183 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature