The Coxiella burnetii effector EmcB is a deubiquitinase that inhibits RIG-I signaling.

ABSTRACT: Eukaryotes have cytosolic surveillance systems to detect invading microorganisms and initiate protective immune responses. In turn, host-adapted pathogens have evolved strategies to modulate these surveillance systems, which can promote dissemination and persistence in the host. The obligate intracellular pathogen Coxiella burnetii infects mammalian hosts without activating many innate immune sensors. The Defect in Organelle Trafficking/Intracellular Multiplication (Dot/Icm) protein secretion system is necessary for C. burnetii to establish a vacuolar niche inside of host cells, which sequesters these bacteria in a specialized organelle that could evade host surveillance systems. However, bacterial secretion systems often introduce agonists of immune sensors into the host cyt

SUBMITTER: Duncan-Lowey J 

PROVIDER: S-EPMC10089202 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature