Filamentous temperature sensitive mutant Z: a putative target to combat antibacterial resistance.

ABSTRACT: In the pre-antibiotic era, common bacterial infections accounted for high mortality and morbidity. Moreover, the discovery of penicillin in 1928 marked the beginning of an antibiotic revolution, and this antibiotic era witnessed the discovery of many novel antibiotics, a golden era. However, the misuse or overuse of these antibiotics, natural resistance that existed even before the antibiotics were discovered, genetic variations in bacteria, natural selection, and acquisition of resistance from one species to another consistently increased the resistance to the existing antibacterial targets. Antibacterial resistance (ABR) is now becoming an ever-increasing concern jeopardizing global health. Henceforth, there is an urgent unmet need to discover novel compounds to combat ABR, which act thr

SUBMITTER: Kifayat S 

PROVIDER: S-EPMC10089256 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature