Impact of BCG vaccination on the repertoire of human γδ T cell receptors.

ABSTRACT:

Introduction

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection is a serious threat to human health. Vaccination with BCG prevents the development of the most severe forms of TB disease in infants and was recently shown to prevent Mtb infection in previously uninfected adolescents. γδ T cells play a major role in host defense at mucosal sites and are known to respond robustly to mycobacterial infection. However, our understanding of the effects of BCG vaccination on γδ T cell responses is incomplete.

Methods

In this study we performed γδ T cell receptor (TCR) repertoire sequencing of samples provided pre- and post-BCG vaccination from 10 individuals to identify specific receptors and TCR clones that are induced by BCG.

Results

Overall, there

SUBMITTER: Xia M 

PROVIDER: S-EPMC10089282 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature