Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing.

ABSTRACT: It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm. H₂ is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability. In this work, we propose a concept of sonocatalytic hydrogen/hole-combined 'inside/outside-cooperation' anti-biofilm for promoting bacteria-infected diabetic wound healing based on two-dimensional piezoelectric nanomaterials. Proof-of-concept experiments using C₃N₄ nanosheets as a representative piezoelectric catalyst with wide band gap and high biosafety have verified that sonocatalytically generated H₂ and holes rapidly penetrat

SUBMITTER: Xu Q 

PROVIDER: S-EPMC10089581 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature