Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4.

ABSTRACT: Amyotrophic lateral sclerosis (ALS) is a heterogenous neurodegenerative disorder that affects motor neurons and voluntary muscle control¹. ALS heterogeneity includes the age of manifestation, the rate of progression and the anatomical sites of symptom onset. Disease-causing mutations in specific genes have been identified and define different subtypes of ALS¹. Although several ALS-associated genes have been shown to affect immune functions², whether specific immune features account for ALS heterogeneity is poorly understood. Amyotrophic lateral sclerosis-4 (ALS4) is characterized by juvenile onset and slow progression³. Patients with ALS4 show motor difficulties by the time that they are in their thirties, and most of them require devices to assi

SUBMITTER: Campisi L 

PROVIDER: S-EPMC10089623 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature