Identification of immune cell infiltration landscape for predicting prognosis of colorectal cancer

ABSTRACT: Abstract

Background

The tumor microenvironment plays an essential role in the therapeutic response to immunotherapy. It is necessary to identify immune cell infiltration (ICI) subtypes for evaluating prognosis and therapeutic benefits. This study aimed to evaluate the ICI score as an effective prognostic biomarker for immune response.

Methods

The cell-type identification by estimating relative subsets of RNA transcripts and the estimation of stromal and immune cells in malignant tumors using expression methods were used to analyse ICI landscapes in 161 colorectal cancer (CRC) samples with patients’ clinical and prognostic data, RNA sequencing data, and whole-exome sequencing data from the Sixth Affiliated Hospital, Sun Yat-sen University (Guangzhou, China). Statistical an

SUBMITTER:  

PROVIDER: S-EPMC10089677 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature