Deletion of LCMR1 in alveolar type II cells induces lethal impairment of lung structure and function in adult mice.

ABSTRACT:

Background

Previous studies of lung cancer metastasis-related protein 1 (LCMR1) mainly focused on its relationship with cancer. However, the function of LCMR1 in normal tissues or cells is poorly understood. We aimed to investigate the effects of alveolar type II cell (AT2 cell)-specific LCMR1 deletion on lung structure and function in adult mice.

Methods

Mice carrying the floxed LCMR1 allele with exons 2-4 flanked by loxP sites were constructed and then crossed with Sftpc-CreER^T2 mice to obtain Sftpc-CreER^T2 ; LCMR1 ^flox/flox for AT2 cell-specific LCMR1 deletion and LCMR1 ^flox/flox mice as littermate control. We observed the body weight change, histopathology, lung wet

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10089867 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature