Development and validation of a novel M1 macrophage-related gene prognostic signature for lung cancer.

ABSTRACT:

Background

Lung cancer (LC) is the most common cancer. Using data from The Cancer Genome Atlas (TCGA), we analyzed the functional roles of M1 macrophage status in LC patients.

Methods

Clinical and transcriptome data of LC patients were obtained from the TCGA dataset. We identified M1 macrophage-related genes in LC patients and investigated the underlying molecular mechanisms of these genes in LC patients. After performing a least absolute shrinkage and selection operator (LASSO) Cox regression analysis, the LC patients were divided into two subtypes, and the underlying mechanism of the association between them was further explored. A comparison of immune infiltration was conducted between the two subtypes. Based on gene set enrichment analysis (GSEA), the key regulators asso

SUBMITTER: Zhu S 

PROVIDER: S-EPMC10089886 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature