Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization.

ABSTRACT: Across the nervous system, neurons with similar attributes are topographically organized. This topography reflects developmental pressures. Oddly, vestibular (balance) nuclei are thought to be disorganized. By measuring activity in birthdated neurons, we revealed a functional map within the central vestibular projection nucleus that stabilizes gaze in the larval zebrafish. We first discovered that both somatic position and stimulus selectivity follow projection neuron birthdate. Next, with electron microscopy and loss-of-function assays, we found that patterns of peripheral innervation to projection neurons were similarly organized by birthdate. Finally, birthdate revealed spatial patterns of axonal arborization and synapse formation to projection neuron outputs. Collectively, we find that

SUBMITTER: Goldblatt D 

PROVIDER: S-EPMC10089979 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature