Leukocyturia and hematuria enable non-invasive differentiation of Bowman's capsule rupture severity in PR3-ANCA glomerulonephritis.

ABSTRACT:

Background

Renal involvement is a common and severe complication of anti-neutrophil cytoplasmic antibody-(ANCA)-associated vasculitis potentially resulting in pauci-immune necrotizing and crescentic ANCA glomerulonephritis (GN) with rapid deterioration of kidney function, progression to end stage kidney disease or, if left untreated, lethal exitus. Analysis of the urinary sediment routinely supports clinical management of ANCA GN, but histopathological implications of aberrancies in the urinary sediment mostly remain elusive. Therefore, we aimed to systematically assess the correlation of aberrancies in the urinary sediment and clinico-pathologic findings.

Methods

A total of 42 kidney biopsies with ANCA GN were retrospectively analyzed in a single-center observational study.

SUBMITTER: Baier E 

PROVIDER: S-EPMC10090024 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature