Cytotoxic Edema and Adverse Clinical Outcomes in Patients with Intracerebral Hemorrhage.

ABSTRACT:

Background

Cytotoxic edema (CE) is an important form of perihematomal edema (PHE), which is a surrogate marker of secondary injury after intracerebral hemorrhage (ICH). However, knowledge about CE after ICH is insufficient. Whether CE has adverse effects on clinical outcomes of patients with ICH remains unknown. Therefore, we aimed to investigate the temporal pattern of CE and its association with clinical outcomes in patients with ICH.

Methods

Data were derived from a randomized controlled study (comparing the deproteinized calf blood extract with placebo in patients with ICH). Intervention in this original study did not show any impact on hematoma and PHE volume, presence of CE, or clinical outcomes. We conducted our analysis in 20 patients who underwent magnetic resonance

SUBMITTER: Li N 

PROVIDER: S-EPMC10090026 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature