Neuronal growth on high-aspect-ratio diamond nanopillar arrays for biosensing applications.

ABSTRACT: Monitoring neuronal activity with simultaneously high spatial and temporal resolution in living cell cultures is crucial to advance understanding of the development and functioning of our brain, and to gain further insights in the origin of brain disorders. While it has been demonstrated that the quantum sensing capabilities of nitrogen-vacancy (NV) centers in diamond allow real time detection of action potentials from large neurons in marine invertebrates, quantum monitoring of mammalian neurons (presenting much smaller dimensions and thus producing much lower signal and requiring higher spatial resolution) has hitherto remained elusive. In this context, diamond nanostructuring can offer the opportunity to boost the diamond platform sensitivity to the required level. However, a comprehens

SUBMITTER: Losero E 

PROVIDER: S-EPMC10090193 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature