TP53 mutation variant allele frequency of ≥10% is associated with poor prognosis in therapy-related myeloid neoplasms.

ABSTRACT: Revised diagnostic criteria for myeloid neoplasms (MN) issued by the International Consensus Classification (ICC) and the World Health Organization (WHO) recommended major change pertaining to TP53-mutated (TP53^mut) MN. However, these assertions have not been specifically examined in therapy-related myeloid neoplasm (t-MN), a subset enriched with TP53^mut. We analyzed 488 t-MN patients for TP53^mut. At least one TP53^mut with variant allele frequency (VAF) ≥ 2% with or without loss of TP53 locus was noted in 182 (37.3%) patients and 88.2% of TP53^mut t-MN had a VAF ≥10%. TP53^mut t-MN with VAF ≥ 10% had a distinct clinical and biological profile compared to both TP53^mut VAF < 10% and wild-type TP53 (TP53^wt)

SUBMITTER: Shah MV 

PROVIDER: S-EPMC10090194 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature