Association of the ADORA2A receptor and CD73 polymorphisms with epilepsy.

ABSTRACT: Single-nucleotide polymorphisms are connected with the risk of epilepsy on occurrence, progress, and the individual response to drugs. Progress in genomic technology is exposing the complex genetic architecture of epilepsy. Compelling evidence has demonstrated that purines and adenosine are key mediators in the epileptic process. Our previous study found the interconnection of P2Y12 receptor single-nucleotide polymorphisms and epilepsy. However, little is known about the interaction between the purine nucleoside A_2A receptor and rate-limiting enzyme ecto-5'-nucleotidase/CD73 and epilepsy from the genetic polymorphism aspect. The aim of the study is to evaluate the impact of A_2AR and CD73 polymorphisms on epilepsy cases. The study group encompassed 181 patients with ep

SUBMITTER: Shi NR 

PROVIDER: S-EPMC10090369 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature