Computational analysis of the flexibility in the disordered linker region connecting LIM domains in cysteine-glycine-rich protein.

ABSTRACT: One of the key proteins that are present in the Z-disc of cardiac tissues, CSRP3, has been implicated in dilated and hypertrophic cardiomyopathy leading to heart failure. Although multiple cardiomyopathy-related mutations have been reported to reside on the two LIM domains and the disordered regions connecting the domains in this protein, the exact role of the disordered linker region is not clear. The linker harbors a few post-translational modification sites and is expected to be a regulatory site. We have carried out evolutionary studies on 5614 homologs spanning across taxa. We also performed molecular dynamics simulations of full-length CSRP3 to show that the length variations and conformational flexibility of the disordered linker could provide additional levels of functional modulat

SUBMITTER: Chauhan PK 

PROVIDER: S-EPMC10090389 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature