The metabolic cost of physical activity in mice using a physiology-based model of energy expenditure.

ABSTRACT:

Objective

Physical activity is a major component of total energy expenditure (TEE) that exhibits extreme variability in mice. Our objective was to construct a general, physiology-based model of TEE to accurately quantify the energy cost of physical activity.

Methods

Spontaneous home cage physical activity, body temperature, TEE, and energy intake were measured with frequent sampling. The energy cost of activity was modeled considering six contributors to TEE (basal metabolic rate, thermic effect of food, body temperature, cold induced thermogenesis, physical activity, and body weight). An ambient temperature of 35 °C was required to remove the contribution from cold induced thermogenesis. Basal metabolic rate was adjusted for body temperature using a Q₁₀ temperatu

SUBMITTER: Skop V 

PROVIDER: S-EPMC10090438 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature