The causal effects of thyroid function and lipids on cholelithiasis: A Mendelian randomization analysis.

ABSTRACT:

Objective

To investigate the relationship between function of thyroid, lipids, and cholelithiasis and to identify whether lipids mediate the causal relationship between function of thyroid and cholelithiasis.

Methods

A Mendelian randomization (MR) study of two samples was performed to determine the association of thyroid function with cholelithiasis. A two-step MR was also performed to identify whether lipid metabolism traits mediate the effects of thyroid function on cholelithiasis. A method of inverse variance weighted (IVW), weighted median method, maximum likelihood, MR-Egger, MR-robust adjusted profile score (MR-RAPS) method, and MR pleiotropy residual sum and outlier test (MR-PRESSO) methods were utilized to obtain MR estimates.

Results

The IVW method revealed t

SUBMITTER: Chen J 

PROVIDER: S-EPMC10090462 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature