Breast density and estradiol are associated with distinct different expression patterns of metabolic proteins in normal human breast tissue in vivo.

ABSTRACT:

Background

Breast density and exposure to sex steroids are major risk factors for breast cancer. The local microenvironment plays an essential role in progression of breast cancer. Metabolic adaption is a major hallmark of cancer. Whether proteins from the extracellular space regulating metabolism are affected in breast cancer, dense breasts or by estrogen exposure are not yet fully elucidated.

Methods

Women with breast cancer, postmenopausal women with normal breast tissue with varying breast density or premenopausal women with breasts exposed to high levels of estradiol were included in the study. Microdialysis was used to collect proteins from the extracellular space in vivo in 73 women; 12 with breast cancer, 42 healthy postmenopausal women with different breast d

SUBMITTER: Ekstrand J 

PROVIDER: S-EPMC10090464 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature