Chronic environmental circadian disruption increases atherosclerosis and dyslipidemia in female, but not male, ApolipoproteinE-deficient mice.

ABSTRACT: Shift work chronically disrupts circadian rhythms and increases the risk of developing cardiovascular disease. However, the mechanisms linking shift work and cardiovascular disease are largely unknown. The goal of this study was to investigate the effects of chronically shifting the light-dark (LD) cycle, which models the disordered exposure to light that may occur during shift work, on atherosclerosis. Atherosclerosis is the progressive accumulation of lipid-filled lesions within the artery wall and is the leading cause of cardiovascular disease. We studied ApolipoproteinE-deficient (ApoE ^-/- ) mice that are a well-established model of atherosclerosis. Male and female ApoE ^-/- mice were housed in control 12L:12D or chronic LD shift

SUBMITTER: Chalfant JM 

PROVIDER: S-EPMC10090465 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature