Use of helminth therapy for management of ulcerative colitis and Crohn's disease: a systematic review.

ABSTRACT: The incidence rate of inflammatory bowel diseases is increasing in developed countries. As such there is an increasing demand for new therapies. The aim of this systematic review was to investigate whether there is evidence to support the use of helminth therapy for the management of Crohn's disease and ulcerative colitis. Four databases (PubMed, Embase, Medline and the Cochrane Central Register of Control Trials) were searched for primary evidence in the form of clinical studies. Nine studies were suitable for inclusion: five double-blind randomized control trials and four open-label studies. This review divided the results of the studies into two categories: (a) the efficacy of helminth therapy and (b) the safety of helminth therapy. Results regarding the efficacy were mixed and a conclu

SUBMITTER: Shields VE 

PROVIDER: S-EPMC10090591 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature