Transcriptomic analysis reveals shared gene signatures and molecular mechanisms between obesity and periodontitis.

ABSTRACT:

Background

Both obesity (OB) and periodontitis (PD) are chronic non-communicable diseases, and numerous epidemiological studies have demonstrated the association between these two diseases. However, the molecular mechanisms that could explain the association between OB and PD are largely unclear. This study aims to investigate the common gene signatures and biological pathways in OB and PD through bioinformatics analysis of publicly available transcriptome datasets.

Methods

The RNA expression profile datasets of OB (GSE104815) and PD (GSE106090) were used as training data, and GSE152991 and GSE16134 as validation data. After screening for differentially expressed genes (DEGs) shared by OB and PD, gene enrichment analysis, protein-protein interaction (PPI) network constructio

SUBMITTER: Cai Y 

PROVIDER: S-EPMC10090675 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature