Eosinophilic esophagitis-associated epithelial remodeling may limit esophageal carcinogenesis.

ABSTRACT:

Introduction

Under homeostatic conditions, esophageal epithelium displays a proliferation/differentiation gradient that is generated as proliferative basal cells give rise to suprabasal cells then terminally differentiated superficial cells. This proliferation/differentiation gradient is often perturbed in esophageal pathologies. Basal cell hyperplasia may occur in patients with gastroesophageal reflux disease (GERD), a condition in which acid from the stomach enters the esophagus, or eosinophilic esophagitis (EoE), an emerging form of food allergy. While GERD is a primary risk factor for esophageal cancer, epidemiological data suggests that EoE patients do not develop esophageal cancer.

Methods

In order to investigate the impact of EoE and esophageal cancer specifically on

SUBMITTER: Fuller AD 

PROVIDER: S-EPMC10090679 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature