Association between salivary microbiota and renal function in renal transplant patients during the perioperative period.

ABSTRACT:

Introduction

Renal transplantation is an effective treatment for the end stage renal disease (ESRD). However, how salivary microbiota changes during perioperative period of renal transplant recipients (RTRs) has not been elucidated.

Methods

Five healthy controls and 11 RTRs who had good recovery were enrolled. Saliva samples were collected before surgery and at 1, 3, 7, and 14 days after surgery. 16S rRNA gene sequencing was performed.

Results

There was no significant difference in the composition of salivary microbiota between ESRD patients and healthy controls. The salivary microbiota of RTRs showed higher operational taxonomic units (OTUs) amount and greater alpha and beta diversity than those of ESRD patients and healthy controls, but gradually stabilized over tim

SUBMITTER: Xiang X 

PROVIDER: S-EPMC10090686 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature