Identification and validation of hub genes in drug induced acute kidney injury basing on integrated transcriptomic analysis.

ABSTRACT:

Background

Drug-induced acute kidney damage (DI-AKI) is a clinical phenomenon of rapid loss of kidney function over a brief period of time as a consequence of the using of medicines. The lack of a specialized treatment and the instability of traditional kidney injury markers to detect DI-AKI frequently result in the development of chronic kidney disease. Thus, it is crucial to continue screening for DI-AKI hub genes and specific biomarkers.

Methods

Differentially expressed genes (DEGs) of group iohexol, cisplatin, and vancomycin's were analyzed using Limma package, and the intersection was calculated. DEGs were then put into String database to create a network of protein-protein interactions (PPI). Ten algorithms are used in the Cytohubba plugin to find the common hub genes.

SUBMITTER: Deng YX 

PROVIDER: S-EPMC10090697 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature