Serum phosphate is not an early predictor of neurocognitive outcomes in acute carbon monoxide poisoning patients.

ABSTRACT:

Objective

Carbon monoxide (CO) poisoning causes brain injury by hypoxia and inflammatory mechanisms. Hypoxic conditions result in increased serum phosphate concentration due to loss of polarity of the cell membrane, changes in membrane fluidity, and consequent destruction of phospholipids in the cell membrane. This study aimed to evaluate whether serum phosphate measured in the emergency department (ED) can serve as an early predictor of neurocognitive sequelae 1 month after acute CO poisoning.

Methods

We included patients ≥16 years with acute CO poisoning from a cohort who were treated at a single tertiary academic hospital in Wonju, Korea, between January 2006 and May 2021. Neurocognitive outcome was assessed using the Global Deterioration Scale score; patients were classi

SUBMITTER: Lee Y 

PROVIDER: S-EPMC10090729 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature