Effects of l-arginine supplementation in patients with sickle cell disease: A systematic review and meta-analysis of clinical trials.

ABSTRACT:

Background and aims

Previous studies have shown that supplementation of some amino acids such as l-arginine or its precursors could exert beneficial effects in patients with sickle cell disease (SCD). The objective of this study is to systematically review the literature to assess the effect of arginine administration on the clinical and paraclinical parameters of patients with SCD.

Methods

Four online databases of PubMed, Web of Sciences, Scopus, and Embase were selected for systematic search. Eligible studies were clinical trials that evaluated the effect of arginine usage in patients with SCD. Effects sizes were calculated using weighted mean difference (WMD) and Hedge's g and they were pooled using random-effects modeling with Hartung-Knapp adjustment. Additional analyse

SUBMITTER: Sadeghi A 

PROVIDER: S-EPMC10090802 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature