Genetic profile of MIF single nucleotide polymorphism (rs755622 G>C) in hepatocellular carcinoma among Egyptian patients.

ABSTRACT:

Aim of the study

To evaluate the role of MIF gene polymorphism rs755622 G>C in occurrence and progression of hepatocellular carcinoma (HCC) among a cohort of Egyptian patients.

Material and methods

This case-control study was conducted on 50 patients with HCC after chronic viral hepatitis and 50 healthy volunteers, recruited between July 2021 and January 2022. All patients with HCC were evaluated for severity of liver disease using a Child-Pugh score, and TNM and BCLC scoring systems. MIF 173 G>C (rs755622) single nucleotide polymorphism was performed for all participants by polymerase chain reaction using restriction fragment length polymorphism technique (RFLP-PCR).

Results

Overall results showed significantly higher frequencies of GG (wild homozygous genotype) and

SUBMITTER: Osman HA 

PROVIDER: S-EPMC10090993 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature