Sleep spindles in the healthy brain from birth through 18 years.

ABSTRACT:

Study objective

Sleep spindles are present from birth and reflect cognitive functions across the lifespan, but normative values for this cognitive biomarker across development are lacking. This study aims to establish normative spindle features over development.

Methods

All available normal 19-channel electroencephalograms from developmentally normal children between February 2002 and June 2021 in the MGH EEG lab were analyzed. Approximately, 20 000 spindles were hand-marked to train and validate an automated spindle detector across ages. Normative values for spindle rate, duration, frequency, refractory period, and interhemispheric lag are provided for each channel and each age.

Results

Sleep EEGs from 567 developmentally normal children (range 0 days to 18 years) we

SUBMITTER: Kwon H 

PROVIDER: S-EPMC10091086 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature