Dysfunction of the cardiac parasympathetic system in fatal familial insomnia: a heart rate variability study.

ABSTRACT:

Study objectives

Although sympathetic hyperactivity with preserved parasympathetic activity has been extensively recognized in fatal familial insomnia (FFI), the symptoms of parasympathetic nervous system failure observed in some patients are difficult to explain. Using heart rate variability (HRV), this study aimed to discover evidence of parasympathetic dysfunction in patients with FFI and the difference of parasympathetic activity between patients with FFI and Creutzfeldt-Jakob disease (CJD).

Methods

This study enrolled nine patients with FFI, eight patients with CJD and 18 healthy controls (HCs) from May 2013 to August 2020. All participants underwent a nocturnal video-polysomnography with lead II electrocardiography, and the data were analyzed using linear and nonlinear

SUBMITTER: Cui Y 

PROVIDER: S-EPMC10091088 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature