Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial.

ABSTRACT:

Importance

Hypertension is the leading risk factor for premature death worldwide. Multiple blood pressure-lowering therapies are available but the potential for maximizing benefit by personalized targeting of drug classes is unknown.

Objective

To investigate and quantify the potential for targeting specific drugs to specific individuals to maximize blood pressure effects.

Design, setting, and participants

A randomized, double-blind, repeated crossover trial in men and women with grade 1 hypertension at low risk for cardiovascular events at an outpatient research clinic in Sweden. Mixed-effects models were used to assess the extent to which individuals responded better to one treatment than another and to estimate the additional blood pressure lowering achievable by pe

SUBMITTER: Sundstrom J 

PROVIDER: S-EPMC10091169 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature