The angiogenic gene profile of pulmonary endarterectomy specimens: Initial study.

ABSTRACT:

Objectives

The underlying mechanisms for the development of chronic thromboembolic pulmonary hypertension and prognostic biomarkers are not clear yet. Thus, our aim is to assess and identify new biomarkers for the expression of 84 key genes linked to angiogenesis.

Methods

Patients who had levels more than 1000 dynes·sec·cm^-5 were included in the test group, and the other patients were included in the control group. Twelve specimens were taken from the patients. RT² Profiler PCR Array (Qiagen) was used to quantify the expression of the 84 key genes.

Results

Eight patients (6 male, 2 female, median age 54.4 ± 13.1 years) who underwent pulmonary endarterectomy were included. Pulmonary vascular resistance improved significantly from 811 ± 390 dyn/s/c

SUBMITTER: Ermerak NO 

PROVIDER: S-EPMC10091285 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature