Ultrasmall superparamagnetic iron oxide nanoparticles for enhanced tumor penetration.

ABSTRACT: The intrinsic pathological characteristics of tumor microenvironments restrict the deep penetration of nanomedicines by passive diffusion. Magnetophoresis is a promising strategy to improve the tumor penetration of nanomedicines aided by the external magnetic propulsive force. However, the research thus far has been focused on large nanoparticles, while ultrasmall superparamagnetic iron oxide (Fe₃O₄) nanoparticles (<∼20 nm) exhibit better performance in many applications such as cancer diagnosis and treatment. Herein, we aim to determine and understand the penetration of ultrasmall Fe₃O₄ nanoparticles with various sizes, shapes, surface charges and magnetizations in a 3D tumor spheroid model. The behaviour of the nanoparticles of three sizes (10,

SUBMITTER: Feng X 

PROVIDER: S-EPMC10091360 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature