Differences in allergen‐specific basophil activation and T cell proliferation in atopic dermatitis patients with comorbid allergic rhinoconjunctivitis treated with a monoclonal anti‐IL‐4Rα antibody or allergen‐specific immunotherapy

ABSTRACT: Abstract

Background

Atopic dermatitis (AD), a chronic inflammatory disorder, is often accompanied by allergic rhinoconjunctivitis (ARC) as a co‐morbidity. The use of a monoclonal anti‐IL‐4Rα antibody has been effective in controlling moderate to severe AD symptoms. Allergen‐specific immunotherapy (AIT) is widely used for the treatment of ARC and asthma. The effects of AIT on basophil reactivity/effector functions have already been examined and used as indicators of the treatment efficacy. However, it is unclear, how an anti‐IL‐4Rα antibody can influence allergen‐specific immune responses of basophils and T cells of AD patients with comorbid ARC.

Objective

To investigate the effect of a monoclonal anti‐IL‐4Rα antibody on the in vitro allergic responses of basophils and T c

SUBMITTER: Layritz A 

PROVIDER: S-EPMC10091378 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature