Comprehensive characterization of FBXW7 mutational and clinicopathological profiles in human colorectal cancers.

ABSTRACT:

Background

FBXW7 is recognized as a critical tumor suppressor gene and a component of the ubiquitin-proteasome system, mediating the degradation of multiple oncogenic proteins, including c-MYC, Cyclin E, c-Jun, Notch, p53. Around 16% of colorectal cancer (CRC) patients carried FBXW7 somatic mutations, while a comprehensive characterization of FBXW7 somatic mutations in CRC is still lacking.

Methods

Colorectal cancer patients with tumor samples and matching white blood cell samples in the past five years were screened and DNA sequenced. DNA sequencing data of MSK MetTropism cohort and RNA sequencing data of TCGA COAD cohort were analyzed.

Results

We discovered that the FBXW7 mutations were associated with higher tumor mutation burden (TMB), higher microsatellite instab

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10091464 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature