Polysaccharides extracted from mulberry fruits (Morus nigra L.): antioxidant effect of ameliorating H₂O₂-induced liver injury in HepG2 cells.

ABSTRACT:

Background

Mori Fructus is an economical and readily available traditional Chinese medicine and food. Polysaccharides in Mori Fructus have clear antioxidant activity and have been found to alleviate oxidative stress (OS)-induced liver damage in experimental studies. The mechanism of regulation of cellular antioxidant activity by mulberry polysaccharides has been suggested to be Nrf2, but it is not clear whether the Nrf2 pathway is mediated by activation of other targets, and the exact process of effects in hepatocytes has yet to be elucidated.

Methods

In this study, the basic characterization of total polysaccharides extracted from mulberry fruits (Morus nigra Linn.) was analyzed. A model of oxidative damage induced by H₂O₂ in HepG2 cells was establishe

SUBMITTER: Li X 

PROVIDER: S-EPMC10091537 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature