Intercellular adhesion molecule 4 and ischemic stroke: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Experimental studies suggested that intercellular adhesion molecule 4 (ICAM-4) might be implicated in ischemic stroke, but the population-based evidence on the relationship between ICAM-4 and ischemic stroke were limited. Herein, we performed a two-sample Mendelian randomization (MR) analysis to investigate the associations of genetically determined plasma ICAM-4 with the risks of ischemic stroke and its subtypes.

Methods

A total of 11 single-nucleotide polymorphisms associated with ICAM-4 were selected as instrumental variables based on the genome-wide association studies (GWAS) with 3,301 European individuals. Summary-level data about ischemic stroke and its subtypes were obtained from the Multi-ancestry GWAS launched by the International Stroke Genetics Consort

SUBMITTER: Sun L 

PROVIDER: S-EPMC10091569 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature